High-throughput ADME assays, contextualized into human PK
Run a complete Tier 1 ADME panel on every compound at the cost you'd typically pay for a single assay. Then contextualize the results with Inductive's AI, using validated, gold standard PK projection methods to guide discovery towards the best compounds.
Running programs based on piecemeal data misses out on promising compounds
Generating high-quality experimental data has been expensive and time-consuming. Comprehensive ADME characterization has been reserved for late-stage lead optimization.
ADME-One changes that equation with automation, making integrated Tier 1 ADME profiling scalable enough to run across entire compound series much earlier in discovery.
One integrated workflow
Microsomal stability
Human liver microsomes
Permeability
MDCK-MDR1 A->B & ER
Kinetic solubility
Protein binding
Human plasma protein binding
CYP inhibition
CYP3A4
Intelligent compound management
PK projections inform your next design cycle
AI-driven human PK projection
*More assays to be added
Individual ADME assays do not tell a complete story
Discovery teams are often forced to balance multiple competing assay readouts independently: improve permeability, maintain solubility, reduce clearance, and avoid CYP liabilities.
Inductive's human PK projection contextualizes ADME-One assay data into a single parameter, helping teams avoid chasing isolated metrics.
Built in partnership with category leaders
Automated data generation
Five common Tier 1 assays executed on validated robotic workflows designed for high-throughput, AI-ready data generation.
AI-driven human PK projection
Best-in-class predictive modeling and state-of-the-art discovery practices contextualize experimental ADME data into actionable human dose projections.
Compound management
Integrated intake, plating, preparation, tracking, and logistics eliminate operational overhead across the workflow.
Validated against real human PK outcomes.
Predictive models should be easy to scrutinize. Explore representative validation data showing how projected human exposure compares to observed clinical pharmacokinetic outcomes.
AI guidance every design cycle
Combine ADME-One with Inductive's Compass predictive ADMET/PK software to rapidly enable highly predictive models when designing and choosing compounds for synthesis.